Brimonidine (bri-MOE-ni-deen, brand names Alphagan and Alphagan-P) is a drug used to treat open-angle glaucoma or ocular hypertension. Alphagan is also used to induce miosis for people suffering from poor night vision after Lasik or PRK surgery.Alpha 2 agonists, through the activation of the Gi GPCR, inhibit the activity of adenylate cyclase. This reduces cAMP and hence Aqueous Humour production by the ciliary body.It acts via decreasing synthesis of aqueous humor, and increasing the amount that drains from the eye. As a treatment for glaucoma, it is usually given in eyedrop form.Brimonidine is an ?2-adrenergic receptor agonist.
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